“Zie je wel… het kan wel in Europa.”
That's what Tim Knotnerus would say about listing his company Agomab on the Nasdaq (see.. It can be done in Europe 🇪🇺✨). When I say he is brave taking such a step, he frames it as strategic and logic. And while many say Europe lacks that strength, he showed that you can build it yourself. Here are a few of the many ways I’ve seen him build that strength.
✨ Preparing for multiple futures
Biotech outcomes are unpredictable, even with excellent science.
Tim plans for every scenario; good, bad, and unlikely, so nothing catches him unprepared.
🧩 Optionality as the foundation of confidence.
Agomab has built real alternatives for all the core elements like pipeline, team, strategy, syndicate, so they do not depend on a single outcome. When you create real alternatives across all core elements, that creates genuine confidence. People feel that.
⚠️ Anticipating roadblocks long before they might appear.
Raising before results, shifting stakeholders before potential misalignment, investing in the next asset before the lead might fail. Strength comes from acting early.
🚴♂️ Truly taking time for reflection
There are so many details that show how Tim reflects. Where I fill my long flights with work, he just thinks and reflects. Where I fill every gap in my agenda, he takes a bike ride or calls a friend to reflect. It shows in the clarity of his decisions.
🌊 Honesty about uncertainty builds more momentum than false certainty ever will.
Tim doesn’t pretend to know the outcome but he is great about laying out the opportunity: if it works, you’ll want to have been part of it, and if you don’t join, your competitors will.
Put these together and the outcome looks bold. I still think it is. But there is also a lot of structure, discipline, and operating from strength.
🚀🇪🇺 Now more than ever I feel that Europe needs to grow from our own strength. And news like this remind us: we absolutely can.
About
Tim Knotnerus is the (Dutch) CEO of the Belgian biotech company Agomab Therapeutics, developing therapies that aim to preserve and restore organ function in fibrotic disease. The company was the first European company in five years to go public on the Nasdaq and Tim is the first Dutch CEO in ten years bringing a company to the Nasdaq stock exchange.

About the author
Eline van Beest
Eline founded the TUDelft spin-off and MedTech scale-up NightBalance in 2009 with a new therapy for sleep apnea. NightBalance was acquired by Philips in 2018. She went on to spin out Hybridize Therapeutics from the LUMC, developing an RNA therapeutic for BK Virus, now outlicensed to AiCuris and currently progressing towards Phase II clinical trial. Currently, she Operating Partner at Thuja Capital and Professor of Practice at the Delft University of Technology. Besides that, she is part of the Investment Committee of the Deep Tech Fund of EZ & InvestNL, the VGZ Voorop in Zorg Fonds and the Graduate Ventures Pre Seed Fund and is a member of the Supervisory Board of Yes!Delft (a leading tech incubator in Europe supporting 280 startups).




